Serum homocysteine level was elevated in ulcerative colitis and can be applied as diagnostic biomarker

Abstract Objective To investigate the correlation between serum level of homocysteine (Hcy) and ulcerative colitis (UC) evaluate its diagnostic performance by pooling open published data. Methods The case–control or cohort studies relevant to Hcy UC, in Pubmed, Medline, EMBASE, China Wanfang CNKI databases, were systematically screened using text word “homocysteine,” “hcy,” “UC,” “inflammatory bowel disease.” standard mean difference (SMD) was pooled through random effect model. sensitivity, specificity area under receiver operating characteristic (AUC) curve for UC also calculated. Results Eighteen identified electronic searching related databases. results indicated that levels statical different healthy controls with SMD = 0.95 (95% CI: 0.87–1.04). 14.30 ± 3.08 (range: 10.10–21.73) 10.09 1.57 6.80–12.47) μmol/L controls, respectively, included 18 studies. Using as biomarker identification, AUC 94.44% 72.71–99.86%), 72.22% (46.52–90.31%) 0.88 0.77–0.99, P < 0.05), respectively. Significant publication bias present work. Conclusion Based on publications, elevated cases can be applied serological marker diagnosis. However, due significant bias, should further validated well-designed prospective